Methyl iodide → HCID 59276543, compound

HRID 2070877Notes

Reaction equation

HRID 2070877 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([CH3:14])[CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=2)[CH:4]=[N:3]1.CC1C=C([N+]([O-])=O)C=C2C=1C=NN2.[H-].[Na+].CI>CN(C)C=O.O>[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([CH3:14])[CH:7]=[C:8]([NH2:11])[CH:9]=2)[CH:4]=[N:3]1

Participants

7

Reactant 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 24728762HCID 24728762, compoundHCID 67293431HCID 67293431, compound

Product 1

HCID 59276543HCID 59276543, compoundYield 59%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent2×

Procedure

1,4-Dimethyl-6-nitro-1H-indazole. 4-Methyl-6-nitro-1H-indazole (0.75 g, 4.23 mmol) was dissolved in N,N-dimethylformamide (10 mL). Sodium hydride (0.203 g, 5.08 mmol, 60% dispersion in mineral oil) was then added at ambient temperature. After 15 minutes, methyl iodide (0.318 mL, 5.08 mmol) in N,N-dimethylformamide (0.5 mL) was added dropwise to the solution and allowed to stir at ambient temperature. After 2 h, LCMS analysis showed two peaks in the UV trace, both with the same product masses as geometric isomers. The solution was condensed under reduced pressure to give a brown solid. The solid was diluted with water (25 mL) and sonicated for 5 minutes. The resultant solid was filtered and washed with additional water followed by hexanes to afford a tan solid. The solid was purified via column chromatography (Biotage, eluting with 0-100% ethyl acetate in hexanes) to afford the title compound (0.480 g, 2.51 mmol, 59% yield) as verified via 1H NMR and NOE NMR. NOE-NMR (400 MHz, DMSO-d6) δ (ppm) 4.18 (Irradiate peak). 1H NMR (400 MHz, DMSO-d6) δ (ppm) 8.55 (s, 1H), 8.35 (s, 1H), 7.77 (s, 1H), 4.18 (s, 3H), 2.66 (s, 3H); MS (ESI) m/z 192.4 [M+1]+.

Workup

  1. waitAfter 2 h
  2. customcondensed under reduced pressure
  3. customto give a brown solid
  4. customsonicated for 5 minutes
  5. filtrationThe resultant solid was filtered
  6. washwashed with additional water
  7. customto afford a tan solid
  8. customThe solid was purified via column chromatography (Biotage, eluting with 0-100% ethyl acetate in hexanes)

Sources & evidence

ORD record
ord-54e3dd1e5f054dcb8eeeff4099594ee5
Source dataset
uspto-grants-2012_10
Patent number
US08299056B2

Reaction notes

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