反应详情

温度

120 °C

To a solution of 3-tert-butylphenyl trifluoromethanesulfonate (1.5 g, 6.70 mmol) in DMF (10 mL), zinc cyanide (1.57 g, 13.40 mmol) was added. The reaction mixture was heated to 120° C. for 4 h. Then reaction mixture was cooled, diluted with ether (2500 mL) and washed twice with 2N ammonium hydroxide (50 mL). The ether solution was washed with brine (20 mL) and concentrated in vacuo to provide the crude mixture. The crude was then purified by column chromatography (5% EtOAc in hexanes) to afford 3-tert-butylbenzonitrile in 75% yield.

1. customThen reaction mixture
2. temperaturewas cooled
3. washwashed twice with 2N ammonium hydroxide (50 mL)
4. washThe ether solution was washed with brine (20 mL)
5. concentrationconcentrated in vacuo
6. customto provide the crude mixture
7. customThe crude was then purified by column chromatography (5% EtOAc in hexanes)