HCID 68670292, compound → HCID 59569980, compound

HRID 2071038Notes

Reaction equation

HRID 2071038 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:12][C:13](=[O:16])[O:14][CH3:15])[CH:6]=[C:7]([C:9]([CH3:11])=[CH2:10])[CH:8]=1>CO.CCOC(C)=O.[Pd]>[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:12][C:13](=[O:16])[O:14][CH3:15])[CH:6]=[C:7]([CH:9]([CH3:11])[CH3:10])[CH:8]=1

Participants

5

Reactant 1

HCID 68670292HCID 68670292, compound

Product 1

HCID 59569980HCID 59569980, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of about 92 mg of crude methyl 3-(aminomethyl)-5-(prop-1-en-2-yl)phenylcarbamate and 17.6 mg of 10% Pd/C in 7 mL of MeOH and 2 mL of EtOAc was stirred at r.t. under H2 balloon for 16 h. The mixture was filtered through Celite and concentrated to give the amine product which was used without further purification.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-9a506bc2cf09482c946527c2ca058f21
Source dataset
uspto-grants-2012_10
Patent number
US08299267B2

Reaction notes

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