反应详情

温度

60 °C

To methyl 2-(3-methoxyphenyl)-2-methylpropanoate (800 mg, 4 mmol) in THF (10 ml) and MeOH (10 ml), aqueous LiOH (excess) was added and the reaction mixture was heated at 60° C. for 7 h. Then volatiles were removed in vacuum and the aqueous layer was extracted with ether. Ether layer was discarded. Then the aqueous layer was acidified and extracted with ethyl acetate. Organic layer was dried with sodium sulfate and volatiles removed under vacuum to yield 2-(3-methoxyphenyl)-2-methylpropanoic acid.

1. customThen volatiles were removed in vacuum
2. extractionthe aqueous layer was extracted with ether
3. extractionextracted with ethyl acetate
4. dry with materialOrganic layer was dried with sodium sulfate and volatiles
5. customremoved under vacuum