反应详情

To a stirred suspension of NaH (0.24 g, 10 mmol, 60% in oil dispersion) in 10 mL of DMF was added dimethyl 5-(methylsulfonamido)isophthalate (1.435 g, 5 mmol) followed by iodomethane (0.62 mL, 10 mmol) at room temperature. After 5 h, the reaction was quenched by H2O (25 mL). Then the reaction mixture was extracted with EtOAc, further washed with H2O to remove excess of DMF, dried over anhydrous Na2SO4 and concentrated. The crude product thus obtained was washed with hexanes to give dimethyl 5-(N-methylmethylsulfonamido)isophthalate as a white solid in 91% (1.37 g) yield.

1. customthe reaction was quenched by H2O (25 mL)
2. extractionThen the reaction mixture was extracted with EtOAc
3. washfurther washed with H2O
4. customto remove excess of DMF
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated
7. customThe crude product thus obtained
8. washwas washed with hexanes