反应详情

To a stirring solution of 216 mg (1.20 mmol) of methyl 4-formyl-6-methylpicolinate in 4 mL of DMF was added 790 mg (1.29 mmol) of Oxone. After about 2 h, 5 mL of 1N HCl and 5 mL of H2O were added, and the aqueous layer was extracted with EtOAc (3×). The combined extracts were dried over Na2SO4, filtered, and concentrated. The desired product (2-(methoxycarbonyl)-6-methylisonicotinic acid) was used in the next reaction without further purification.

1. extractionthe aqueous layer was extracted with EtOAc (3×)
2. dry with materialThe combined extracts were dried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated
5. customThe desired product (2-(methoxycarbonyl)-6-methylisonicotinic acid) was used in the next reaction without further purification