1-Iodopropane → HCID 21413304, compound

HRID 2071247Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][C:13]3[C:12](=[O:15])[CH:11]=[C:10]([C:16]([O:18][CH3:19])=[O:17])[NH:9][C:8]=3[C:7](=[O:20])[C:6]=2[CH:21]=1.[CH2:22](I)[CH2:23][CH3:24]>>[CH2:22]([N:9]1[C:10]([C:16]([O:18][CH3:19])=[O:17])=[CH:11][C:12](=[O:15])[C:13]2[O:14][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:21][C:6]=3[C:7](=[O:20])[C:8]1=2)[CH2:23][CH3:24]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 12736928HCID 12736928, compound

Product 1

HCID 21413304HCID 21413304, compoundYield 35%

Procedure

Prepared from methyl 8-chloro-4,10-dihydro-4,10-dioxo-1H-1-benzopyrano-[3,2-b]pyridine-2-carboxylate (4.5 g, 0.015 mole) and n-propyl iodide (9.1 g, 0.054 mole) by the method described for Ex. 7. Recrystallization from methanol gave white crystals (1.77 g, 35%), m.p. 240°-244°.

Workup

customRecrystallization from methanol

Sources & evidence

ORD record: ord-63774bae2cec47b284c352dd6f0be3f9
Source dataset: uspto-grants-1977_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04046769

Reaction notes

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