Trimethyl phosphite → HCID 53801769, compound

HRID 2071364Notes

Reaction equation

Cl[CH2:2][C:3](=[N:13][NH:14][C:15]([NH2:17])=[O:16])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][N:7]=1.[P:18]([O:23]C)([O:21][CH3:22])[O:19][CH3:20]>>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3](=[N:13][NH:14][C:15]([NH2:17])=[O:16])[CH2:2][P:18](=[O:23])([O:21][CH3:22])[O:19][CH3:20])=[N:7][CH:8]=1

Participants

Reactant 2

HCID 8472Trimethyl phosphite

HCID 53838671HCID 53838671, compound

Product 1

HCID 53801769HCID 53801769, compound

Procedure

1-Chloro-3-(5-chloropyrid-2-yloxy)-2-semicarbazonopropane (322 mg.) and trimethyl phosphite (720 mg.) were mixed and heated at 70°-100° C., with stirring, for 11/2 hours. The mixture was evaporated to dryness, finally under high vacuum, to give dimethyl 3-(5-chloropyrid-2-yloxy)-2-semicarbazonopropylphosphonate, RF = 0.15 (5% v/v methanol in ethyl acetate), the required starting material.

Workup

temperatureheated at 70°-100° C.
customThe mixture was evaporated to dryness, finally under high vacuum

Sources & evidence

ORD record: ord-baafb1bd45884c4d8bae38bf0341e69e
Source dataset: uspto-grants-1977_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04046841

Reaction notes

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