Hydrogen Bromide → 4-(Piperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

HRID 2071414Notes

Reaction equation

HRID 2071414 reaction equation
Cl.C[O:3][C:4]1[CH:5]=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[O:10]C.[BrH:18]>>[BrH:18].[OH:3][C:4]1[CH:5]=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[OH:10]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 214137803-(3,4-Dimethoxyphenyl)piperidine hydrochloride

Product 1

HCID 30462094-(Piperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

Procedure

A solution of 5 g of the hydrochloride of Step C in 25 ml of 66% hydrobromic acid was heated at 115° C. for an hour and excess hydrobromic acid was removed under reduced pressure. The residue was empasted with ethyl acetate and was crystallized from ethanol to obtain 3.85 g of 3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide melting at 224° C.

Workup

  1. customexcess hydrobromic acid was removed under reduced pressure
  2. customwas crystallized from ethanol

Sources & evidence

ORD record
ord-eba4f089f731430fa43b8ae31ba8113a
Source dataset
uspto-grants-1977_09
Patent number
US04046901

Reaction notes

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