Methylamine → HCID 178482312, compound

HRID 2071609Notes

Reaction equation

HRID 2071609 reaction equation
Cl[C:2]1[C:11]([CH3:13])([CH3:12])[C:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([OH:14])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:21][NH2:22]>C(O)C.N1C=CC=CC=1>[CH3:12][C:11]1([CH3:13])[C:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([OH:14])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[NH:22][CH3:21]

Participants

5

Reactant 2

HCID 6329MethylamineHCID 214117332-Chloro-3,3-dimethyl-4-phenyl-3,4-dihydro-4-quinolinol

Product 1

HCID 178482312HCID 178482312, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1049PyridineSolvent

Procedure

2-Chloro-3,4-dihydro-3,3-dimethyl-4-phenylquinolin-4-ol (1.43g., 0.005 mole) was dissolved in a mixture of a 33% w/v solution of methylamine in ethanol (40 ml.) and pyridine (0.79g.). The solution was stirred for four hours, after which the methylamine and ethanol were evaporated off to leave a residue, which was recrystallised twice from isopropyl alcohol to give the title compound (0.96g., m.p. 192° - 194° C).

Workup

  1. customafter which the methylamine and ethanol were evaporated off
  2. customto leave a residue, which
  3. customwas recrystallised twice from isopropyl alcohol

Sources & evidence

ORD record
ord-fe42325fe5804467a0252f344b831b76
Source dataset
uspto-grants-1977_09
Patent number
US04048177

Reaction notes

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