Carbon Dioxide → HCID 54373755, compound

HRID 2072401Notes

Reaction equation

HRID 2072401 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][N:3]=1.[C:12](=[O:14])=[O:13].[CH2:15](OCC)[CH3:16]>C(OC(OC(OCC)=O)=O)C>[CH2:15]([O:13][C:12]([N:3]1[C:2]([NH2:1])=[C:10]2[C:5]([CH:6]=[C:7]([Cl:11])[CH:8]=[CH:9]2)=[N:4]1)=[O:14])[CH3:16]

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 3283Diethyl EtherHCID 856286-chloro-1H-indazol-3-amine

Product 1

HCID 54373755HCID 54373755, compound

Reagents, catalysts & solvents 1

HCID 3051Diethyl PyrocarbonateSolvent

Procedure

0.3 mol of 3-amino-6-chloroindazole in 250 ml of pyrocarbonic acid diethyl ester are heated, while stirring, to 50° C for about 5 hours, until the evolution of CO2 has ceased. After cooling, 250 ml of diethyl ether are added and 90% of theory of 3-amino-6-chloroindazole-2-carboxylic acid ethyl ester are isolated, by filtration, in the form of yellow crystals. Melting point: 163°-165° C.

Workup

  1. temperatureAfter cooling

Sources & evidence

ORD record
ord-bc913b5f65574c3baacfe4421d93939e
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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