HCID 54200407, compound → HCID 54395129, compound

HRID 2072413Notes

Reaction equation

HRID 2072413 reaction equation
C(OC([N:6]1[C:14]2[C:9](=[CH:10][C:11]([C:21]([F:24])([F:23])[F:22])=[CH:12][C:13]=2[NH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:8]([NH2:25])=[N:7]1)=O)C>CN(C)C=O>[CH2:19]([O:18][C:16]([N:7]1[C:8]([NH2:25])=[C:9]2[C:14]([C:13]([NH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12][C:11]([C:21]([F:23])([F:24])[F:22])=[CH:10]2)=[N:6]1)=[O:17])[CH3:20]

Participants

3

Reactant 1

HCID 54200407HCID 54200407, compound

Product 1

HCID 54395129HCID 54395129, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Analogously to Example 24, 0.025 mol of 3-amino-5-trifluoromethyl-7-ethoxycarbonylaminoindazole-2-carboxylic acid ethyl ester in 30 ml of dimethylformamide gives 3-amino-5-trifluoromethyl-7-ethoxycarbonylaminoindazole-1-carboxylic acid ethyl ester (melting point: 236°-237° C; 65% of theory) in 1 hour at 155° C.

Sources & evidence

ORD record
ord-17e8ebd013e74400995cb2714a3eb1e4
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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