Benzene → HCID 21409291, compound

HRID 2072435Notes

Reaction equation

HRID 2072435 reaction equation
C1C=CC=CC=1.C(Cl)(Cl)Cl.[CH3:11][NH:12][C:13](=[O:23])[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[C:17]([CH3:22])[CH:16]=1.[Cl:24][CH:25]([CH3:29])[C:26](Cl)=[O:27]>C(N(CC)CC)C>[CH3:11][NH:12][C:13](=[O:23])[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:26](=[O:27])[CH:25]([Cl:24])[CH3:29])=[C:17]([CH3:22])[CH:16]=1

Participants

6

Reactant 4

HCID 241BenzeneHCID 6212ChloroformHCID 25072AminomatacilHCID 1110192-Chloropropionyl chloride

Product 1

HCID 21409291HCID 21409291, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Utilizing benzene and chloroform as the solvent and triethylamine as the acid acceptor, 3-methyl-4-aminophenyl N-methylcarbamate (2.5g., 0.0139 mole) was reacted with α-chloropropionyl chloride (1.79g., 0.0141 mole) to yield the desired product as a white powder (3.6g.). Recrystallization from ethanol/water to give material with m.p. 167°-70° C.

Sources & evidence

ORD record
ord-0c82a491c74243f594d6042cec90b4b8
Source dataset
uspto-grants-1977_09
Patent number
US04051254

Reaction notes

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