HCID 21409301, compound → HCID 53751002, compound

HRID 2072439Notes

Reaction equation

HRID 2072439 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:15])[CH:5]=[C:6]([CH3:14])[C:7]=1[NH:8][C:9](=[O:13])[CH2:10][O:11][CH3:12]>CN=C=O.C1(CC#N)C=CC=CC=1.C(N(CC)CC)C>[CH3:7][NH:8][C:9](=[O:13])[O:15][C:4]1[CH:3]=[C:2]([CH3:1])[C:7]([NH:8][C:9](=[O:13])[CH2:10][O:11][CH3:12])=[C:6]([CH3:14])[CH:5]=1

Participants

5

Reactant 1

HCID 21409301HCID 21409301, compound

Product 1

HCID 53751002HCID 53751002, compound

Reagents, catalysts & solvents 3

HCID 8471TriethylamineCatalystHCID 8794PhenylacetonitrileCatalystHCID 12228Methyl IsocyanateCatalyst

Procedure

3,5-Dimethyl-4-methoxyacetamidophenol (0.8g., 0.0038 mole, m.p. 169°-73° C., prepared by reaction of methoxyacetyl chloride with 3,5-dimethyl-4-aminophenol) was reacted with methyl isocyanate (0.245g., 0.004 mole) in benzeneacetonitrile using a few drops of triethylamine as a catalyst. After stirring the initially clear reaction solution for about two days, the precipitated product was filtered (0.6g., m.p. 179.5°-82° C.).

Workup

  1. filtrationthe precipitated product was filtered (0.6g., m.p. 179.5°-82° C.)

Sources & evidence

ORD record
ord-ab50a27359bb451184fbf50a48bfaa5d
Source dataset
uspto-grants-1977_09
Patent number
US04051254

Reaction notes

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