Hydrochloric Acid → 1-Phenyl-8-[(cis-1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one, hydrochloride

HRID 2072460Notes

Reaction equation

HRID 2072460 reaction equation
[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][C@H:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[C@H:19]4[OH:28])[CH2:13][CH2:12]3)[C:10](=[O:29])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:30]>CCOCC>[ClH:30].[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][C@H:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[C@H:19]4[OH:28])[CH2:13][CH2:12]3)[C:10](=[O:29])[NH:9][CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54521082HCID 54521082, compound

Product 1

HCID 1317109021-Phenyl-8-[(cis-1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one, hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-Phenyl-8-[(cis-1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one (4.0 g) is slurried in ether and treated with excess ethereal hydrogen chloride. The resulting mixture is cooled for 16 hours and the resulting precipitate is collected to yield 3.9 g of the title compound, melting point 254°-255° C.

Workup

  1. temperatureThe resulting mixture is cooled for 16 hours
  2. customthe resulting precipitate is collected

Sources & evidence

ORD record
ord-cbea349b108a41eeafdaa3ddfd9ddb53
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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