Hydrochloric Acid → HCID 131710904, compound

HRID 2072462Notes

Reaction equation

HRID 2072462 reaction equation
[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][C@@H:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=5)[C@H:19]4[OH:30])[CH2:13][CH2:12]3)[C:10](=[O:31])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>CCOCC>[ClH:32].[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][C@@H:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=5)[C@H:19]4[OH:30])[CH2:13][CH2:12]3)[C:10](=[O:31])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53792200HCID 53792200, compound

Product 1

HCID 131710904HCID 131710904, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-Phenyl-8-[(trans-1,2,3,4-tetrahydro-1-hydroxy-6-methoxy-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]-decan-4-one (2.5 g) is suspended in 100 ml of anhydrous ether and treated with one equivalent of ethereal hydrogen chloride. The resulting mixture is stirred at room temperature for one hour and then cooled. The precipitate is collected and washed with additional ether to yield 2.4 g of the title compound, melting point 258°-260° C.

Workup

  1. temperaturecooled
  2. customThe precipitate is collected
  3. washwashed with additional ether

Sources & evidence

ORD record
ord-b95b6fd494ed4b389a09a5af3c78c5ab
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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