Hydrochloric Acid → 1-[(1,2,3,4-Tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotonitrile, hydrochloride

HRID 2072482Notes

Reaction equation

HRID 2072482 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[CH2:12][N:13]1[CH2:20][CH2:19][C:16]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:17]#[N:18])[CH2:15][CH2:14]1.[ClH:28]>C(O)C>[ClH:28].[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[CH2:12][N:13]1[CH2:20][CH2:19][C:16]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:17]#[N:18])[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 538211251-[(1,2,3,4-Tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotonitrile

Product 1

HCID 1317109081-[(1,2,3,4-Tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotonitrile, hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Finely-ground 1-[(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotonitrile (5.0 g) is slurried in absolute ethanol and treated with 1.2 equivalents of ethereal hydrogen chloride. The resulting mixture is cooled and filtered to yield the title compound.

Workup

  1. temperatureThe resulting mixture is cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-48a7c1a3158041ad889a3637bd84b500
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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