Hydrochloric Acid → HCID 131710913, compound

HRID 2072488Notes

Reaction equation

HRID 2072488 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH2:8][CH2:7][CH2:6]2.[ClH:16].[CH3:17][NH:18][CH3:19].[CH2:20]=O.Cl>CC(C)=O.C(O)C>[ClH:16].[CH3:17][N:18]([CH2:20][CH:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([C:2]([F:14])([F:15])[F:1])[CH:4]=2)[C:9]1=[O:13])[CH3:19]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 712Formaldehyde2×HCID 10473Dimethylamine, hydrochlorideHCID 149151176-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one

Product 1

HCID 131710913HCID 131710913, compoundYield 77.3%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 702EthanolSolvent

Procedure

A mixture of 6-(trifluoromethyl)-1-tetralone (0.90 g), dimethylamine hydrochloride (0.42 g), paraformaldehyde (0.16 g), and 95% ethanol (2 ml) containing concentrated hydrogen chloride (0.02 ml) is heated on a steam bath for 1 1/2 hours. The reaction mixture soon becomes homogeneous and the paraformaldehyde dissolves. The warm solution is diluted with acetone (15 ml) and cooled to yield the title compound as white needles (1.0 g) melting point 137°-138° C.

Workup

  1. temperatureis heated on a steam bath for 1 1/2 hours
  2. temperaturecooled

Sources & evidence

ORD record
ord-d1e58b26508347cbbd8b91c582559e2c
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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