Hydrochloric Acid → HCID 131710917, compound

HRID 2072495Notes

Reaction equation

HRID 2072495 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8]([CH2:12][N:13]3[CH2:29][CH2:28][C:16]4([N:20]([C:21]5[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=5)[CH2:19][NH:18][C:17]4=[O:27])[CH2:15][CH2:14]3)=[CH:9]2)=[CH:4][CH:3]=1.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8]([CH2:12][N:13]3[CH2:29][CH2:28][C:16]4([N:20]([C:21]5[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=5)[CH2:19][NH:18][C:17]4=[O:27])[CH2:15][CH2:14]3)=[CH:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21408245HCID 21408245, compound

Product 1

HCID 131710917HCID 131710917, compoundYield 160.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8-[(7-Chloro-3,4-dihydro-2-naphthalenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (1.6 g) is dissolved in 100 ml of absolute ethanol and treated with excess ethereal hydrogen chloride to give the crude hydrochloride salt. The crude salt is crystallized from methanol to yield 1.4 g of the title compound, melting point 274°-275° C.

Workup

  1. customto give the crude hydrochloride salt
  2. customThe crude salt is crystallized from methanol

Sources & evidence

ORD record
ord-d2f5118deb504715951d3eb2be531c3d
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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