Hydrochloric Acid → HCID 22104533, compound

HRID 2072496Notes

Reaction equation

HRID 2072496 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]2[CH2:8][CH2:9][CH2:10][C:11](=[O:12])[C:5]2=[CH:4][C:3]=1[CH3:13].[ClH:14].[CH3:15][NH:16][CH3:17].[CH2:18]=O.Cl>C(O)C>[ClH:14].[CH3:15][N:16]([CH2:18][CH:10]1[CH2:9][CH2:8][C:6]2[C:5](=[CH:4][C:3]([CH3:13])=[C:2]([CH3:1])[CH:7]=2)[C:11]1=[O:12])[CH3:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 3084576,7-Dimethyl-1-tetralone

Product 1

HCID 22104533HCID 22104533, compoundYield 74.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A mixture of 10.0 g of 6,7-dimethyl-α-tetralone, 6.0 g of dimethyl amine hydrochloride, 2.2 g of paraformaldehyde, and 12 ml of 95% ethanol containing .15 ml of concentrated hydrogen chloride is heated on a steam bath for 3 hours. After the mixture has been heating for a short time, an additional 20 ml of 95% ethanol is added. The mixture is cooled, yielding a crystalline mass that is washed with absolute ethanol to give 11.5 g of the title compound, melting point 204°-205° C.

Workup

  1. temperatureis heated on a steam bath for 3 hours
  2. temperatureAfter the mixture has been heating for a short time
  3. temperatureThe mixture is cooled
  4. customyielding a crystalline mass that
  5. washis washed with absolute ethanol

Sources & evidence

ORD record
ord-92f6765b19c742c6abc4bae6e7a8c8bb
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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