Hydrochloric Acid → HCID 131710918, compound

HRID 2072498Notes

Reaction equation

HRID 2072498 reaction equation
[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][CH:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][C:22]([CH3:29])=[C:23]([CH3:28])[CH:24]=5)[C:19]4=[O:30])[CH2:13][CH2:12]3)[C:10](=[O:31])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>C(O)C>[ClH:32].[C:1]1([N:7]2[C:11]3([CH2:12][CH2:13][N:14]([CH2:17][CH:18]4[CH2:27][CH2:26][C:25]5[C:20](=[CH:21][C:22]([CH3:29])=[C:23]([CH3:28])[CH:24]=5)[C:19]4=[O:30])[CH2:15][CH2:16]3)[C:10](=[O:31])[NH:9][CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21408202HCID 21408202, compound

Product 1

HCID 131710918HCID 131710918, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Phenyl-8-[(1,2,3,4-tetrahydro-6,7-dimethyl-1-oxo-2-naphthalenyl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one (15.0 g) is slurried in 150 ml of absolute ethanol and treated with 1.2 equivalents of ethereal hydrogen chloride. The resulting mixture is stirred at room temperature for 1 hour and then filtered to yield 14.7 g of the title compound, melting point 260°-262° C.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-2c923d802a5c42c5ae2b01862118a867
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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