反应详情

To a solution of 0.288 g. of 2-(5-oxo-5H-dibenzo[a,d]cyclohepten-2-yl)propanal in 4 ml. of ethanol is added a solution of 0.12 g. of hydroxylamine hydrochloride and 0.11 g. of sodium hydroxide in 0.4 ml. of water. The mixture is refluxed briefly, then acidified with dilute hydrochloric acid and extracted with ethyl acetate. The extract is washed, dried and evaporated to yield a crude product which is chromatographed on silica gel, eluting with chloroform:methanol (19:1) to afford 2-(5-oxo-5H-dibenzo[a,d]cyclohepten-2-yl)propanal oxime.

1. temperatureThe mixture is refluxed briefly
2. extractionextracted with ethyl acetate
3. washThe extract is washed
4. customdried
5. customevaporated
6. customto yield a crude product which
7. customis chromatographed on silica gel
8. washeluting with chloroform:methanol (19:1)