Propargylamine → N-[3-(2,4-Dichlorophenoxy)propyl]prop-2-yn-1-amine

HRID 2072622Notes

Reaction equation

HRID 2072622 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][CH2:6][CH2:7]Br.[CH2:14]([NH2:17])[C:15]#[CH:16]>CC#N.O>[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][NH:17][CH2:14][C:15]#[CH:16]

Participants

5

Reactant 2

HCID 239041PropargylamineHCID 2494271-(3-bromopropoxy)-2,4-dichlorobenzene

Product 1

HCID 12738587N-[3-(2,4-Dichlorophenoxy)propyl]prop-2-yn-1-amine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

2.3 ml of 87% pure 3-(2,4-dichlorophenoxyl) propylbromide (2.99 g; 0.011 mole) and 1.6 ml propargylamine (1.38 g; 0.025 mole) in 30 ml CH3CN and 1.65 g k2CO3 in 3 ml H2O were stirred at room temperature for 5 days.

Sources & evidence

ORD record
ord-7cf97d5e7fe44f1e8bd3165edd7751f9
Source dataset
uspto-grants-1990_04
Patent number
US04913891

Reaction notes

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