Potassium Carbonate → HCID 178442417, compound

HRID 2072623Notes

Reaction equation

HRID 2072623 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][C:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[CH2:20]([C@H:23]1[CH2:28][CH2:27][C@H:26]([CH2:29]Br)[CH2:25][CH2:24]1)[CH2:21][CH3:22].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:20]([C@H:23]1[CH2:28][CH2:27][C@H:26]([CH2:29][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:13]=[N:12][C:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:10][N:9]=3)=[CH:6][CH:7]=2)[CH2:25][CH2:24]1)[CH2:21][CH3:22]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1360140782-p-Hydroxyphenyl-5-n-hexylpyrazineHCID 178447937HCID 178447937, compound

Product 1

HCID 178442417HCID 178442417, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 11 g of 2-p-hydroxyphenyl-5-n-hexylpyrazine, 7.8 g of trans-4-n-propyl-1-bromomethylcyclohexane, 8.6 g of potassium carbonate and 50 ml of dimethylformamide is heated at 90° for 10 hours. Customary working up gives 4-(5-n-hexylpyrazin-2-yl)-phenyl trans-4-n-propylcyclohexylmethyl ether.

Workup

  1. temperatureis heated at 90° for 10 hours

Sources & evidence

ORD record
ord-a45828ba68e440ae99f8fdcd5f5ff30f
Source dataset
uspto-grants-1990_04
Patent number
US04913837

Reaction notes

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