2-(Methylamino)ethanol → HCID 14499650, compound

HRID 2072663Notes

Reaction equation

HRID 2072663 reaction equation
Cl[CH2:2][C:3]([N:5]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].[CH3:12][NH:13][CH2:14][CH2:15][OH:16].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[O:4]=[C:3]([N:5]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH2:2][N:13]([CH3:12])[CH2:14][CH2:15][OH:16]

Participants

5

Reactant 3

HCID 80162-(Methylamino)ethanolHCID 11430Potassium CarbonateHCID 31441341-(Azepan-1-yl)-2-chloroethan-1-one

Product 1

HCID 14499650HCID 14499650, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 4.8 g (27 mmol) of 1-(2-chloroacetyl)perhydroazepine, dissolved in 40 ml of 2-butanone, 3.6 g (48 mmol) of 2-(methylamino)ethanol and 6.6 g (48 mmol) of potassium carbonate is heated to 70° C. for 5 h.

Sources & evidence

ORD record
ord-3c3f4f5e6e19474282e52d69a70037bf
Source dataset
uspto-grants-1990_04
Patent number
US04914092

Reaction notes

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