Benzoyl Peroxide → HCID 13648813, compound

HRID 2072678Notes

Reaction equation

HRID 2072678 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]2[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:10][CH:11]=[C:4]2[N:3]=1.[Cl:18]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]2[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:10][C:11]([Cl:18])=[C:4]2[N:3]=1

Participants

5

Reactant 3

HCID 7187Benzoyl PeroxideHCID 31398ChlorosuccinimideHCID 13457646HCID 13457646, compound

Product 1

HCID 13648813HCID 13648813, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A mixture of 2,4-dichloro-6-phenylimidazo[1,5-a]pyrimidine (0.88 g), N-chlorosuccinimide (0.5 g) and benzoyl peroxide (0.04 g) in carbon tetrachloride (20 ml) was heated to reflux for 14 hours. The mixture was concentrated and purified by alumina column chromatography, eluting with benzene to give the objective product which was recrystallized from ethanol to yellow plates (0.32 g), mp 133°-134° C.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 14 hours
  3. concentrationThe mixture was concentrated
  4. custompurified by alumina column chromatography
  5. washeluting with benzene
  6. customto give the objective product which
  7. customwas recrystallized from ethanol to yellow plates (0.32 g), mp 133°-134° C.

Sources & evidence

ORD record
ord-491132ad6dff42ce94a2aa62a1f9e007
Source dataset
uspto-grants-1990_04
Patent number
US04914104

Reaction notes

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