1H-Benzimidazole-2-acetonitrile → 2-(1H-1,3-benzodiazol-2-yl)ethanethioamide

HRID 2072800Notes

Reaction equation

HRID 2072800 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[CH2:10][C:11]#[N:12].P([O-])(OCC)(SCC)=[S:14]>CN(C)C=O>[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[CH2:10][C:11]([NH2:12])=[S:14]

Participants

4

Reactant 2

HCID 204551H-Benzimidazole-2-acetonitrileHCID 53249491Diethyldithiophosphate

Product 1

HCID 49625382-(1H-1,3-benzodiazol-2-yl)ethanethioamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using the procedure of Preparation A3, 2.0 g of 2-benzimidazoleacetonitrile and 2.3 ml of diethyl dithiophosphate in 10 ml of dimethylformamide gave 150 mg of the titled compound.

Sources & evidence

ORD record
ord-fcc0251ac4f1471abddb626446621957
Source dataset
uspto-grants-1990_04
Patent number
US04914207

Reaction notes

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