Hydrochloric Acid → 2-Methoxybenzene-1-carbothioamide

HRID 2072801Notes

Reaction equation

HRID 2072801 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[C:5]#[N:6].C([S:13]P([O-])(OCC)=S)C.Cl>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[C:5]([NH2:6])=[S:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 810862-MethoxybenzonitrileHCID 53249491Diethyldithiophosphate

Product 1

HCID 27597312-Methoxybenzene-1-carbothioamide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 6.5 g of o-methyoxybenzonitrile and 8.22 ml of diethyldithiophosphate in 200 ml of ethyl aceate was saturated with hydrogen chloride gas, and the resulting reaction mixture allowed to stir overnight at room temperature. The solvent was removed in vacuo and the oily residue triturated with hexane. The resulting solid was filtered and dried, 3.6 g.

Workup

  1. customthe resulting reaction mixture
  2. customThe solvent was removed in vacuo
  3. customthe oily residue triturated with hexane
  4. filtrationThe resulting solid was filtered
  5. customdried

Sources & evidence

ORD record
ord-74377e0c003444d78d6783a23d3caf2b
Source dataset
uspto-grants-1990_04
Patent number
US04914207

Reaction notes

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