Hydrochloric Acid → HCID 23037389, compound

HRID 2072964Notes

Reaction equation

HRID 2072964 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([NH:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Cl>C(O)(C)C>[OH2:19].[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:16]([CH2:17][C:18]([NH:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14390216HCID 14390216, compound

Product 1

HCID 23037389HCID 23037389, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Solid 2-(4-chlorophenyl)-N-(3-pyridinyl)-3H-imidazo[4,5-b]pyridine-3-acetamide (0.50 g) was dissolved in isopropyl alcohol and acidified with excess ethereal hydrogen chloride to produce a crystalline precipitate. The solid was collected, washed with ether, and dried under high vacuum at room temperature overnight to give 0.58 g (91%), mp 189°-91° C.

Workup

  1. customto produce a crystalline precipitate
  2. customThe solid was collected
  3. washwashed with ether
  4. customdried under high vacuum at room temperature overnight
  5. customto give 0.58 g (91%), mp 189°-91° C.

Sources & evidence

ORD record
ord-61ba374e0d0a455eabd1aee9e326a973
Source dataset
uspto-grants-1990_04
Patent number
US04914109

Reaction notes

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