Trifluoroacetic acid → 4-(4-Chlorophenylsulfonylamino)pyrrolidine trifluoroacetate

HRID 2073266Notes

Reaction equation

HRID 2073266 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]2[CH2:16][NH:15][CH2:14][CH2:13]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH:12]2[CH2:16][NH:15][CH2:14][CH2:13]2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 179145054-(4-Chlorophenylsulfonylamino)pyrrolidine

Product 1

HCID 867438494-(4-Chlorophenylsulfonylamino)pyrrolidine trifluoroacetate

Procedure

(2S,4R)-1-t-Butoxycarbonyl-2-[(E and Z)-5-carboxy-5-methyl-1-hexenyl]-4-(4-chlorophenylsulfonylamino)pyrrolidine obtained in Example 20(1) was dissolved in 75% aqueous trifluoroacetic acid (8 ml) and the solution was stirred at room temperature for 1 hour. The solvent was evaporated in vacuo to give (2S,4R)-2-[(E and Z)-5-carboxy-5-methyl-1-hexenyl]-4-(4-chlorophenylsulfonylamino)pyrrolidine trifluoroacetate as an oil.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-3b08eeb31e774b7ab47470e803e6d7ed
Source dataset
uspto-grants-1990_04
Patent number
US04916152

Reaction notes

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