Potassium Iodide → HCID 19857169, compound

HRID 2073487Notes

Reaction equation

HRID 2073487 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[CH2:9][CH2:10][CH2:11]Cl)=[CH:4][CH:3]=1.[N:21]1(C(OCC)=O)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(C(C)=O)C(C)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[CH2:9][CH2:10][CH2:11][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 11430Potassium CarbonateHCID 19857181HCID 19857181, compound

Product 1

HCID 19857169HCID 19857169, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

50 g (0.17 mol) of 4,5-bis(4-fluorophenyl)pentyl chloride, 32.5 g (0.21 mol) of ethyl piperazine-1-carboxylate, 46.9 g (0.34 mol) of powdered potassium carbonate and 2.8 g of potassium iodide were reacted in 580 ml of methyl isobutyl ketone and the mixture was worked up, by a process analogous to that described in Example 3d).

Sources & evidence

ORD record
ord-cc8624ffbf294356a488ae190a2f277e
Source dataset
uspto-grants-1990_04
Patent number
US04918073

Reaction notes

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