Methyl (4,6-dimethoxypyrimidin-2-yl)carbamate → HCID 15077136, compound

HRID 2073695Notes

Reaction equation

[CH2:1]([O:3][C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[S:10]([NH2:13])(=[O:12])=[O:11])[CH3:2].[CH3:14][O:15][C:16]1[CH:21]=[C:20]([O:22][CH3:23])[N:19]=[C:18]([NH:24][C:25](=O)[O:26]C)[N:17]=1.C[Al](C)C>>[CH2:1]([O:3][C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[S:10]([NH:13][C:25]([NH:24][C:18]1[N:17]=[C:16]([O:15][CH3:14])[CH:21]=[C:20]([O:22][CH3:23])[N:19]=1)=[O:26])(=[O:11])=[O:12])[CH3:2]

Participants

Reactant 3

HCID 13314628Methyl (4,6-dimethoxypyrimidin-2-yl)carbamate

HCID 150771235-Ethoxy-2-methyl-1,3-thiazole-4-sulfonamide

HCID 16682925Trimethylaluminum

Product 1

HCID 15077136HCID 15077136, compoundYield 49.7%

Procedure

By employing the procedure described in Example 2, the reaction of 1.33 g of 5-ethoxy-2-methyl-4-thiazolesulfonamide with 1.4 g of methyl N-(4,6-dimethoxypyrimidin-2-yl)carbamate in the presence of 3.3 ml of a 2.0M solution of trimethylaluminum, there was obtained 1.2 g of the title compound, m.p. 140°-143°. IR: 1710 cm-1 (C=O).

Sources & evidence

ORD record: ord-f25b56920c35439c95556f8cbc1e290e
Source dataset: uspto-grants-1990_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04919706

Reaction notes

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