反应详情

α-(3-(4-(2-quinolinylmethyloxy)phenoxymethyl)phenoxy)acetonitrile (8.12 mmol), sodium azide (24.4 mmol) and ammonium chloride (24.4 mmol) in dimethylformamide (10 ml) are heated at 115°-120° C. for 6 hrs. After cooling, the reaction mixture is diluted with ethyl acetate (150 ml), washed with water (6×100 ml) then dried and evaporated. The residue is chromatographed on a column of silica gel (360 g) and eluted with a gradient of isopropanol in methylene chloride to give 5-(3-(4-(2-quinolinylmethyloxy)phenoxymethyl)phenoxymethyl)tetrazole. (M.P. 131°-132° C.)

1. temperatureAfter cooling
2. washwashed with water (6×100 ml)
3. customthen dried
4. customevaporated
5. customThe residue is chromatographed on a column of silica gel (360 g)
6. washeluted with a gradient of isopropanol in methylene chloride