Trifluoroacetic acid → HCID 178525854, compound

HRID 2074112Notes

Reaction equation

HRID 2074112 reaction equation
[F:1][C:2]1[CH:45]=[CH:44][C:5]([CH2:6][C:7]2[N:11]([CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])[N:10]=[C:9]([C:20]3[N:21]=[CH:22][N:23](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:24]=3)[CH:8]=2)=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:45]=[CH:44][C:5]([CH2:6][C:7]2[N:11]([CH2:12][C:13]([OH:15])=[O:14])[N:10]=[C:9]([C:20]3[N:21]=[CH:22][NH:23][CH:24]=3)[CH:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68360284HCID 68360284, compound

Product 1

HCID 178525854HCID 178525854, compoundYield 83.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of tert-butyl [5-(4-fluorobenzyl)-3-(1-trityl-1H-imidazol-4-yl)-1H-pyrazol-1-yl]acetate (0.5 g, 0.80 mmol) in CH2Cl2 (10 mL) was added dropwise TFA (10 mL) at 0° C. After the addition, the mixture was stirred at 0° C. for 2 hours. The solvent was removed in vacuo and the residue was washed with Et2O (3×10 mL) and dried in oven to yield the title compound (0.2 g, 80.0%) as a white solid.

Workup

  1. additionAfter the addition
  2. customThe solvent was removed in vacuo
  3. washthe residue was washed with Et2O (3×10 mL)
  4. customdried in oven

Sources & evidence

ORD record
ord-4d3b58bb3c9b4aa8be38dec19f5c1a97
Source dataset
uspto-grants-2011_04
Patent number
US07919488B2

Reaction notes

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