Propylamine → HCID 57869854, compound

HRID 20744Notes

Reaction equation

HRID 20744 reaction equation
CO[C:3](=[O:13])[CH2:4][CH2:5][O:6][N:7]=[C:8]([O:10][CH2:11][CH3:12])[CH3:9].[CH2:14]([NH2:17])[CH2:15][CH3:16]>CO>[CH2:11]([O:10][C:8](=[N:7][O:6][CH2:5][CH2:4][C:3](=[O:13])[NH:17][CH2:14][CH2:15][CH3:16])[CH3:9])[CH3:12]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 71331645Methyl 3-{[(1-ethoxyethylidene)amino]oxy}propanoate

Product 1

HCID 57869854HCID 57869854, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
55 °C

Procedure

To a known compound, 3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) were added methanol (3 ml) and n-propylamine (1.3 ml), and the mixture was stirred at 55° C. for 15 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-propylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (296 mg, 86% yield).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-cdbdab0d045348dd836917e4c0d1343b
Source dataset
uspto-grants-2010_06
Patent number
US07745663B2

Reaction notes

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