Methylamine → HCID 57869858, compound

HRID 20746Notes

Reaction equation

HRID 20746 reaction equation
C[O:2][C:3](=O)[CH2:4][CH2:5][O:6][N:7]=[C:8]([O:10][CH2:11][CH3:12])[CH3:9].[CH3:14][NH2:15]>CO>[CH2:11]([O:10][C:8](=[N:7][O:6][CH2:5][CH2:4][C:3](=[O:2])[NH:15][CH3:14])[CH3:9])[CH3:12]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 71331645Methyl 3-{[(1-ethoxyethylidene)amino]oxy}propanoate

Product 1

HCID 57869858HCID 57869858, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of a known compound, 3-(1-ethoxyethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 41.3 g, 0.218 mol) in methanol (150 ml) was added methylamine (40% solution in methanol, 200 ml) at room temperature, and the mixture was stirred at 60° C. for 12 hours. The reaction mixture was concentrated under reduced pressure to give N-(2-methylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (41.0 g, 100%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0f42f8336615425993af73d3ecc9da46
Source dataset
uspto-grants-2010_06
Patent number
US07745663B2

Reaction notes

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