反应详情

A solution of dihydrochloride of Compound 18 (400 mg, 1.09 mmol) in THF (20 mL) was added with ethylamine (177 mg, 2.18 mmol) and 1,1′-carbonyldiimidazole (352 mg, 2.18 mmol), followed by stirring at room temperature for 1.5 hours. The reaction mixture was added with water and was extracted with ethyl acetate. The organic layer was washed with saturated brine, and was dried over anhydrous magnesium sulfate. The solvent was evaporated and the residue was purified by preparative thin-layer chromatography (chloroform/acetone=1/1) to obtain Compound 48 (350 mg, 44%).

1. extractionwas extracted with ethyl acetate
2. washThe organic layer was washed with saturated brine
3. dry with materialwas dried over anhydrous magnesium sulfate
4. customThe solvent was evaporated
5. customthe residue was purified by preparative thin-layer chromatography (chloroform/acetone=1/1)