反应详情

The product obtained using (E)-4-[2-(1H-indazol-3-yl)vinyl]benzoic acid (1.50 g, 5.68 mmol), sarcosine ethyl ester hydrochloride (1.05 g, 6.81 mmol), 1-hydroxybenzotriazole monohydrate (1.31 g, 6.81 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.63 g, 8.52 mmol) and N-methylmorpholine (1.87 mL, 17.0 mmol) in a similar manner to Example 5, was neutralized by adding 2 mol/L aqueous sodium hydroxide solution (20 ml), and the mixture was filtered to obtain (E)-N-methyl-N-carboxymethyl-4-[2-(1H-indazol-3-yl)vinyl]benzamide (1.04 g, 55%).

1. customThe product obtained
2. filtrationthe mixture was filtered