反应详情

The crude product (174 mg) obtained using Compound 18 (200 mg, 0.602 mmol), N-methylmorpholine (0.132 mL, 1.20 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (161 mg, 0.842 mmol), 1-hydroxybenzotriazole monohydrate (106 mg, 0.783 mmol) and (3-methylbutyrylamino)acetic acid (115 mg, 0.722 mmol) in a similar manner to Example 5, was purified by silica gel column chromatography (chloroform/methanol=80/20), followed by triturating in mixed solvent of ethyl acetate/ethanol to obtain Compound 126 (105 mg, 37%).

1. customwas purified by silica gel column chromatography (chloroform/methanol=80/20)
2. customby triturating in mixed solvent of ethyl acetate/ethanol