反应详情

温度

-78 °C

4-Trifluoromethyl-thiazole-2-carboxylic acid ethyl ester (131 mg) was dissolved in THF (5 ml). The reaction mixture was then cooled to −78° C. DIBAL-H (4.7 ml, 1.0 M in tetrahydrofurane) was added slowly during a period of 10 min. The cooling bath was removed, and the solution was kept under stirring for 30 min at RT. The solution was then cooled to 0° C., and NaF (784 mg) was added, followed by the slow addition of 3 ml water. The product was extracted by ethyl acetate. The solvent was removed, and the crude product was used in alkylation reactions without further purification.

1. customThe cooling bath was removed
2. temperatureThe solution was then cooled to 0° C.
3. additionNaF (784 mg) was added
4. additionfollowed by the slow addition of 3 ml water
5. extractionThe product was extracted by ethyl acetate
6. customThe solvent was removed
7. customthe crude product was used in alkylation reactions without further purification