反应详情

In a nitrogen atmosphere, to a suspension of palladium hydroxide (20% by weight; 90 mg) in methanol (2.7 ml), a solution of Compound 48 (500 mg, 0.462 mmol) in methanol (3.6 ml) was added; after the nitrogen atmosphere was replaced with a hydrogen atmosphere, stirring was conducted at room temperature for about 6 hours. After a nitrogen atmosphere was restored, ethyl acetate (about 20 ml) was added, and the mixture was filtered on silica gel and washed with an ethyl acetate solution containing 10% methanol. Concentration under reduced pressure was conducted to yield a crude product of Compound 49.

1. filtrationthe mixture was filtered on silica gel
2. washwashed with an ethyl acetate solution
3. additioncontaining 10% methanol
4. concentrationConcentration under reduced pressure