Acetic Acid → HCID 58926503, compound

HRID 2075704Notes

Reaction equation

HRID 2075704 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:13][N:14]=[C:7]1[CH:6]=[N:5]2.OO.C(O)(=[O:25])C>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:13][N:14]=[C:7]1[C:6](=[O:25])[NH:5]2

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 784Hydrogen Peroxide2×HCID 58926527HCID 58926527, compound

Product 1

HCID 58926503HCID 58926503, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

7-Bromo-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline (7.4 g, 22.7 mmol), hydrogen peroxide (30%, 59 mL), and acetic acid (185 mL) were combined and heated at 50° C. overnight. Additional hydrogen peroxide (30%, 15 mL) was added to push the reaction to completion, and the mixture was stirred overnight at room temperature. The reaction was added to water (550 mL) and the precipitate was filtered and rinsed with water to give the desired product, 7a.

Workup

  1. customthe reaction to completion
  2. filtrationthe precipitate was filtered
  3. washrinsed with water

Sources & evidence

ORD record
ord-b2cc85b9cea947ab928baf3f7df98fd9
Source dataset
uspto-grants-2011_04
Patent number
US07919621B2

Reaction notes

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