Piperidine → Tert-butyl 4-(cyclopropanecarbonylamino)-3-hydroxypiperidine-1-carboxylate

HRID 207667Notes

Reaction equation

HRID 207667 reaction equation
[CH:22]1([C:25](=[O:26])[Cl:27])[CH2:23][CH2:24]1.[NH2:7][CH:8]1[CH:9]([OH:21])[CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]1.[NH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1>>[NH:7]([CH:8]1[CH:9]([OH:21])[CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]1)[C:25]([CH:22]1[CH2:23][CH2:24]1)=[O:26]

Participants

4

Reactant 3

HCID 8082PiperidineHCID 77637Cyclopropanecarbonyl chlorideHCID 21874161tert-Butyl 4-amino-3-hydroxypiperidine-1-carboxylate

Product 1

HCID 69160239Tert-butyl 4-(cyclopropanecarbonylamino)-3-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-6913af23ab104cd2ac5227fff22538f5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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