Carbamazepine → HCID 67108016, compound

HRID 2076729Notes

Reaction equation

HRID 2076729 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:16]([NH2:18])=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[C:19]1(=[O:26])[CH:24]=[CH:23][C:22](=[O:25])[CH:21]=[CH:20]1.C1COCC1>CO>[CH:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([NH2:18])=[O:17])[C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[CH:7]=[CH:8][C:9]=2[CH:10]=1.[C:19]1(=[O:26])[CH:24]=[CH:23][C:22](=[O:25])[CH:21]=[CH:20]1

Participants

5

Reactant 3

HCID 2554CarbamazepineHCID 4650QuinoneHCID 8028Tetrahydrofuran

Product 1

HCID 67108016HCID 67108016, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

25 mg (0.1058 mmol) carbamazepine and 11 mg (0.1018 mmol) benzoquinone was dissolved in 2 mL methanol or THF. Slow evaporation of the solvent produced an average yield of yellow crystals of a 1:1 carbamazepine/benzoquinone co-crystal, as shown in FIG. 57A-B.

Workup

  1. customevaporation of the solvent

Sources & evidence

ORD record
ord-33dffa4888f8422f9546f53a90b4a3a0
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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