HCID 67099238, compound → HCID 11625232, compound

HRID 2076797Notes

Reaction equation

HRID 2076797 reaction equation
C(OC(=O)[NH:7][C@@:8]([CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[CH:29][CH:28]=1)([CH3:24])[C@H:9]([O:11][P:12]([O:19]C(C)(C)C)([O:14]C(C)(C)C)=[O:13])[CH3:10])(C)(C)C>Cl.CO>[NH2:7][C@:8]([CH3:24])([CH2:25][CH2:26][C:27]1[CH:28]=[CH:29][C:30]([O:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[CH:31][CH:32]=1)[C@H:9]([O:11][P:12](=[O:13])([OH:19])[OH:14])[CH3:10]

Participants

4

Reactant 1

HCID 67099238HCID 67099238, compound

Product 1

HCID 11625232HCID 11625232, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

{(1R,2R)-2-(Di-tert-butoxy-phosphoryloxy)-1-[2-(4-heptyloxy-phenyl)-ethyl]-1-methyl-propyl}-carbamic acid tert-butyl ester (40 mg, 0.067 mMol) is dissolved in a saturated solution of HCl in methanol (5 ml) and stirred at RT for 24 hours. The solvent is evaporated under reduced pressure. Lyophilisation from dioxane/H2O (3:1) gives the title compound as a white, amorphous powder.

Workup

  1. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-3654c2efccf54bdb940099d882e0cc3a
Source dataset
uspto-grants-2011_04
Patent number
US07928093B2

Reaction notes

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