Hydrochloric Acid → HCID 67099642, compound

HRID 2077028Notes

Reaction equation

HRID 2077028 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([C:15]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][C:21]([O:29][CH3:30])=[C:22]([O:27][CH3:28])[CH:23]=3)[CH2:18]2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C>CCOCC.C(OCC)(=O)C>[ClH:1].[CH3:28][O:27][C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][C:21]=1[O:29][CH3:30])[CH2:18][N:17]([C:15]([CH:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1)=[O:16])[CH2:26][CH2:25]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 38411395HCID 38411395, compound

Product 1

HCID 67099642HCID 67099642, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 5 N hydrochloric acid in Et2O (15 ml) was added to a solution of 4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester (3 g, 7.43 mmol) in ethyl acetate and the mixture was stirred for 2 hours at room temperature. The precipitate formed was collected by filtration and the white solid obtained was identified as (6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(piperidin-4-yl)-methanone hydrochloride (2.1 g, 95% yield).

Workup

  1. customThe precipitate formed
  2. filtrationwas collected by filtration
  3. customthe white solid obtained

Sources & evidence

ORD record
ord-2cb35d2be43e4b1f906a4fda69e6f063
Source dataset
uspto-grants-2011_04
Patent number
US07928121B2

Reaction notes

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