Hydrochloric Acid → HCID 67097843, compound

HRID 2077033Notes

Reaction equation

HRID 2077033 reaction equation
[CH2:1]([C:8]1[N:9]=[CH:10][C:11]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13][C:12]=2[N:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[CH2:1]([C:8]1[N:9]=[CH:10][C:11]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13][C:12]=2[N:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 250705822-benzyl-6,7,8,9-tetrahydro-5H-pyriMido[4,5-d]azepine

Product 1

HCID 67097843HCID 67097843, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine of Example 54 (415 mg, 1.73 mmol) was dissolved in dioxane (5 ml) and treated with 4 M HCl in dioxane (1 ml) and stirred overnight. The dioxane was decanted off and the residue washed with ether and then dried in vacuo to give the pure product as a colourless solid. (430 mgs, 74.7%)

Workup

  1. customThe dioxane was decanted off
  2. washthe residue washed with ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-64f766ebc0114485bd7a3feabd6fb111
Source dataset
uspto-grants-2011_04
Patent number
US07928099B2

Reaction notes

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