Triethylamine → HCID 59312308, compound

HRID 2077050Notes

Reaction equation

HRID 2077050 reaction equation
[CH2:1]([C:8]1[N:9]=[C:10](Cl)[C:11]2[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:14][CH2:13][C:12]=2[N:23]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:32][N:33]1[CH:37]=[C:36]([CH2:38][NH2:39])[CH:35]=[N:34]1>CN(C)C(=O)C>[CH2:21]([O:20][C:18]([N:15]1[CH2:16][CH2:17][C:11]2[C:10]([NH:39][CH2:38][C:36]3[CH:35]=[N:34][N:33]([CH3:32])[CH:37]=3)=[N:9][C:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:23][C:12]=2[CH2:13][CH2:14]1)=[O:19])[CH3:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 671225(1-methyl-1H-pyrazol-4-yl)methanamineHCID 59312295HCID 59312295, compound

Product 1

HCID 59312308HCID 59312308, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

A solution of ethyl 2-benzyl-4-chloro-5,6,8,9-tetrahydro-pyrimido[4,5-d]azepine-7-carboxylate of Step B (50 mg, 0.14 mmol), triethylamine (0.10 ml, 0.72 mmol) and C-(1-Methyl-1H-pyrazol-4-yl)-methylamine (50 mg, 0.45 mmol) in N,N-dimethylacetamide (2.0 ml) was stirred for 18 h at 60° C. The solvent was removed in vacuo and the crude product was deprotected without further purification. LRMS APCI m/z 421 [MH]+.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe crude product was deprotected without further purification

Sources & evidence

ORD record
ord-2bc0b5bf1f624405af1cd6dec10925b0
Source dataset
uspto-grants-2011_04
Patent number
US07928099B2

Reaction notes

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