Trifluoroacetic acid → HCID 23146261, compound

HRID 2077275Notes

Reaction equation

HRID 2077275 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1)=O)(C)(C)C.FC(F)(F)C(O)=O.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[NH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 11430Potassium CarbonateHCID 86625768HCID 86625768, compound

Product 1

HCID 23146261HCID 23146261, compoundYield 29.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(RS)-2-Benzooxazol-2-ylmethyl-piperidine-1-carboxylic acid tert butyl ester (0.50 g) in dichloromethane (8 ml) was cooled (ice-bath) and trifluoroacetic acid (2 ml) added. The mixture was stirred with ice-cooling for 4 h, poured onto saturated potassium carbonate (20 ml) and extracted with dichloromethane. The combined extracts were dried (MgSO4) and solvent removed at reduced pressure to give the title compound (0.10 g)

Workup

  1. additionadded
  2. temperaturecooling for 4 h
  3. extractionextracted with dichloromethane
  4. dry with materialThe combined extracts were dried (MgSO4) and solvent
  5. customremoved at reduced pressure

Sources & evidence

ORD record
ord-6f6564fe8cde44ea856bf7eb9060759f
Source dataset
uspto-grants-2011_04
Patent number
US07928124B2

Reaction notes

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