反应详情

A microwave reaction vial was charged with 6-bromo-2-chlorobenzo[d]thiazole (300 mg, 1.21 mmol), propan-2-amine (75 mg, 1.27 mmol), triethylamine (183 mg, 1.81 mmol) and 2.4 mL DMF. The vial was sealed, and the mixture was irradiated in the microwave for 20 min at 150° C. The reaction mixture was concentrated twice from toluene and purified by silica gel chromatography (0-50% 90/10 CH2Cl2/MeOH in CH2Cl2), which provided 6-bromo-N-isopropylbenzo[d]thiazol-2-amine (210 mg, 64%) as a white solid. MS (ESI pos. ion) m/z calc'd for C10H11BrN2S: 271.2/273.2. found 271.0/273.0.

1. customA microwave reaction
2. customThe vial was sealed
3. customthe mixture was irradiated in the microwave for 20 min at 150° C
4. concentrationThe reaction mixture was concentrated twice from toluene
5. custompurified by silica gel chromatography (0-50% 90/10 CH2Cl2/MeOH in CH2Cl2), which